Endocrine Abstracts

Introduction: Nuclear retinoid receptors (RARs) upon a ligand binding act as all-trans retinoic acid-inducible transcription factors interacting as heterodimers with nuclear retinoid X (rexinoid) receptors (RXRs). The disruption of retinoic acid (RA) signalling pathways is believed to underlie the etiology of a number of malignancies. Retinoids – cell differentiation agents that may ‘reprogram’ tumours, i.e. retinoic acid derivatives or retinoic acid related com...